NOT KNOWN FACTS ABOUT CONOLIDINE FOR NERVE PAIN

Most recently, it has been discovered that conolidine and the above derivatives act to the atypical chemokine receptor 3 (ACKR3. Expressed in very similar parts as classical opioid receptors, it binds to a wide array of endogenous opioids. Unlike most opioid receptors, this receptor acts being a scavenger and does not activate a 2nd messenger proce